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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
STX1A
All Species:
48.79
Human Site:
S259
Identified Species:
82.56
UniProt:
Q16623
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16623
NP_004594.1
288
33023
S259
K
K
A
V
K
Y
Q
S
K
A
R
R
K
K
I
Chimpanzee
Pan troglodytes
XP_001146754
288
33051
S259
K
K
A
V
K
Y
Q
S
K
A
R
R
K
K
I
Rhesus Macaque
Macaca mulatta
NP_001028037
288
32987
S259
K
K
A
V
K
Y
Q
S
K
A
R
R
K
K
I
Dog
Lupus familis
XP_849756
293
33456
S264
K
K
A
V
K
Y
Q
S
K
A
R
R
K
K
I
Cat
Felis silvestris
Mouse
Mus musculus
O35526
288
33036
S259
K
K
A
V
K
Y
Q
S
K
A
R
R
K
K
I
Rat
Rattus norvegicus
P32851
288
33049
S259
K
K
A
V
K
Y
Q
S
K
A
R
R
K
K
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001233551
316
35842
S287
K
K
A
V
K
Y
Q
S
K
A
R
R
K
K
I
Frog
Xenopus laevis
NP_001086322
286
32704
S257
K
K
A
V
K
F
Q
S
D
A
R
R
K
K
I
Zebra Danio
Brachydanio rerio
NP_571598
288
33347
S258
K
K
A
V
K
Y
Q
S
Q
A
R
K
K
K
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24547
291
33630
S262
K
K
A
L
K
Y
Q
S
K
A
R
R
K
K
I
Honey Bee
Apis mellifera
XP_393760
291
33455
S263
K
K
A
L
K
Y
Q
S
K
A
R
R
P
V
C
Nematode Worm
Caenorhab. elegans
O16000
291
33234
S260
K
K
A
V
Q
Y
Q
S
K
A
R
R
K
K
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SRV7
306
34701
K272
T
K
A
V
K
S
Q
K
S
S
R
K
W
M
C
Baker's Yeast
Sacchar. cerevisiae
P39926
295
33715
R261
N
K
A
V
K
S
A
R
K
A
R
K
N
K
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93
98.9
93.1
N.A.
98.2
98.6
N.A.
N.A.
85.7
67.3
82.9
N.A.
70
69.4
63.2
N.A.
Protein Similarity:
100
95.4
98.9
94.5
N.A.
98.9
99.3
N.A.
N.A.
89.8
85.7
93.4
N.A.
83.1
81.4
80
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
86.6
86.6
N.A.
93.3
73.3
93.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
93.3
100
N.A.
100
80
100
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.2
24.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.3
47.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
60
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
100
0
0
0
8
0
0
93
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
15
% C
% Asp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
86
% I
% Lys:
86
100
0
0
93
0
0
8
79
0
0
22
79
86
0
% K
% Leu:
0
0
0
15
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% P
% Gln:
0
0
0
0
8
0
93
0
8
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
8
0
0
100
79
0
0
0
% R
% Ser:
0
0
0
0
0
15
0
86
8
8
0
0
0
0
0
% S
% Thr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
86
0
0
0
0
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
0
0
0
0
79
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _